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KMID : 0882420120830040525
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Korean Journal of Medicine
2012 Volume.83 No. 4 p.525 ~ p.528
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A Case of Cardiogenic Shock after Chemotherapy with 5-Fluorouracil and Leucovorin in Rectal Cancer
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Yoon Jee-Hee
Kim Dong-Hyun
Kim Seung-Hun
Choi Won-Young
Koh Young-Il
Chung Ik-Joo
Bae Woo-Kyun
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Abstract
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A 51-year-old man with rectal adenocarcinoma was admitted to hospital for neoadjuvant concurrent chemoradiotherapy. Three days after receiving 5-fluorouracil (425 mg/m2) and leucovorin (20 mg/m2) chemotherapy, the patient complained of chest pain. The patient had no history of cardiac disease. Electrocardiography showed ST segment elevation in leads II, III, and aVF, but the cardiac enzymes were normal. Transthoracic echocardiography revealed global hypokinesia with marked systolic dysfunction (ejection fraction 21.55%) and coronary angiography showed no significant stenosis. Unfortunately, he died of cardiogenic shock, despite intensive medical treatment.
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KEYWORD
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5-Fluorouracil, Cardiogenic shock, Rectal cancer
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